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phenobarbital will decrease the extent or influence of olanzapine/samidorphan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Strong CYP3A4 inducers decrease amounts of olanzapine and samidorphan by~50% and ~75% respectively.phenobarbital will lower the level or impact of diclofenac by affecting hepatic enzyme